Wyndham Grand Weifang, China
brain-wave treatment for alzheimer\'s is promising, but the first human subject is left behind
by：EME LIGHTING
2020-06-13
Peg Gleason, 83, who lives in San Francisco, was the first person to sign up for the first human trial at MIT.
Experimental treatment of Alzheimer\'s disease was supported in last January.
The trial had a slightly odd environment in the warehouse office of TheraNova, San Francisco --based medical-
Equipment developers
Seven days a week, lasting seven months until the end of the study, 85-year-old Pegg and her husband Ed, Uber got off at the side door and was taken to a small room inside an old metal vault.
The experimenters are \"very good and smart people, they are all 32-and-a-half-
Ed, a retired product manager at & t, joked.
In a telephone interview, he said: \"They put very large sunglasses on the Peg and the lenses were blackened . \" Peg also took part in a telephone interview. “[They]
Attach very small LED lights to them so that when you turn them on, all you see is four small lights on each lens.
They will be calibrated to flash at 40Hz.
\"Along with the glasses, the Peg installed the headset, which played the tone at a frequency of 40Hz, and each hand had a cushion vibrating at that frequency.
The treatment lasted an hour a day and then another 15 minutes.
A cognitive test was conducted and the scavenger was driven home.
The San Francisco experiment began in last January. a month ago, the journal Nature published a research report from the Massachusetts Institute of Technology that was exposed to a flashing led light at 40Hz (
40 cycles per second)
Related to a significant reduction in betaStarch-like plaque
Abnormal protein mass-
In the visual cortex of mice developing Alzheimer\'s diseaselike disease.
Neurons in the brain sometimes move synchronously, producing brain waves.
Brain waves around 40Hz, in so-
Called gamma band.
Frequency associated with higher frequency
Sequential cognitive functions such as working memory and spatial navigation
It is well known that Alzheimer\'s disease and some other brain damageBased on disease.
Also destroyed the gamma properties ofmice improved varieties to develop Alzheimer\'s disease, Li, professor of neurology at the Massachusetts Institute of Technology
Cai Huixin, the lead author of Nature, explained this in a speech to the congressional panel on last July.
But she said that it took only one hour a day in the experimental mice in a box with LED lights, and after flashing at 40Hz, their gamma-ray brain waves bounced back and the starch-like plaques were reduced by half.
Mice can learn again.
\"They can remember an object in the environment, they can remember a place, they can navigate better,\" Tsai said . \".
TSAI ING-WEN said what happened
Hertz flashes the brain waves of the \"carrying\" mouse, synchronized at gamma frequency.
She said that the sync was initially shown on a cat in her 1990 s, pointing to a GIF where a cat stared at the flashing lights.
At present, it is not clear what is going on. TSAI ING-WEN continued, but the gamma-ray brain waves that restored mice also restored their small nerve cells, clear toxic substances such as starch-like protein and \"strike\" brain immune cells in Alzheimer\'s disease.
\"These gatekeeper cells, the small nerve cells, are active again,\" Cai said . \"
\"They are getting bigger and bigger, the branches are getting more complicated, and there are only more branches.
But more importantly, they are busy digesting the starch-like protein.
TSAI ING-WEN said another sign of Alzheimer\'s disease, nerve fiber winding, \"disappeared\" in experimental mice.
The blood vessels in their brains have also changed, lumens
Internal channel-
Double expansion.
\"But it didn\'t stop,\" she said . \"
\"In the brain of Alzheimer\'s, a large number of neurons die and the brain becomes smaller.
\"Contact 40-6 to 8 weeks a day
However, Hertz light \"protects brain cells from death and prevents brain atrophy.
Synaptic connections, density, are restored.
The most spectacular thing is that what makes Tsai English \"Speechless\" is that this effect spreads to other parts of the brain, \"including the hippocampus of the memory center, the prefrontal cortex is a part of the brain that is known to be important for decision-making and execution.
However, when the light stops, starch-like patches bounce back even if it is only 12 hours.
The frequency of flashing must reach 40Hz;
Other frequencies or random flashes have no effect.
TSAI ING-WEN and her colleagues checked and reviewed their findings.
\"We\'re excited, but we\'re anxious,\" she said . \"
\"This is an incredible and unexpected result.
We just have this anxiety, repeat as much as we can, and let as many different people repeat as possible.
\"In my wildest dreams, I never thought I \'d come across this kind of observation, this kind of deep, this kind of hard --to-
Tsai, head of the Institute for Learning and Memory at the Massachusetts Institute of Technology Picower, said on the podcast.
Last fall, shortly before the publication of the journal Nature, Tsai and her leading colleagues
The author is Edward, a professor at MIT.
Boyden founded a company called cognitive therapy.
With the support of MIT and the venture capital fund, the company aims to develop \"equipment-
Basic therapy for Alzheimer\'s and other neurological degeneration.
Cognito participated in the human feasibility study in San Francisco in last January.
Ed and Peg Gleason learned about this from a leaflet delivered by a friend at the University of California Medical Center.
They have nothing to lose;
Alzheimer\'s is the most common form of dementia and there is no cure yet.
It won\'t die soon, but as the brain gradually fails and the victim loses all the ability to communicate or take care of himself, it will last for months or years.
Alzheimer\'s disease is now the third leading cause of death in the United States.
In 2011, Peg was diagnosed when MRI at the time of routine physical examination found her frontal lobe atrophy.
\"When she explained that it was Alzheimer\'s, I looked at her and said, \'No, no, that\'s not me, I don\'t have any problems, \'she said. \'.
She ran out of the doctor\'s office crying.
Six years after that, she
The term memory has declined.
She rarely remembers what happened earlier in the day, or even something memorable, like a visit from one of their six children.
But within a few days after the start of the TheraNova trial, the memory of Peg was improved.
She began to remember what happened the day before, not always, but more often.
Their children commented on this.
After the meeting, peeger also seemed a bit pleased to tell ed that she felt good.
\"It will last two or three hours after each treatment,\" Ed said . \".
The researchers also seem optimistic about the results.
Two staff members told Ed that everyone in the pilot study
A total of 5 people signed up
There is progress.
However, about a month after the start of the trial, the experimenter announced the suspension of the trial.
\"They said, \'We are going to stop this study and make an assessment, \'said Ed. \'
\"I don\'t know what they\'re thinking.
I don\'t want to think we are guinea pigs and they want to see if there is a negative effect of a recession.
But within a few days, the DingTalk fell.
Ed said: \"I told them that the plaque is coming back;
Like fog from the ocean.
\"The researchers did not make it clear.
\"They will say, \'Time is up for the study and we will review where we are.
\"Eight days later, Ed got a call saying the trial was recovering and a car would pick them up again the next day.
After that, there was no rest at the daily meeting except for a few weekends until noonAugust.
Then, with a week and a half notice, the study was over.
The trials are being transferred to Boston, where Cognito headquarters is located, the researchers said.
Soon, Pegg fell again.
By the end of September, five weeks after the study ended, her short-term income dropped significantlyterm memory.
Ed said: \"her anxiety and sunset became more obvious and more chaotic.
She didn\'t recognize Ed for the first time.
Several times she thought Ed was her father.
She also walked twice, something that had not happened before.
Her grandmother and sister died of Alzheimer\'s disease two years ago.
\"One thing I want to know,\" said peeger, \"is how much I will expect.
I don\'t want to hurt him and the children.
As the trial drew to a close, Ed began to ask researchers to allow Peg to continue her daily treatment or to help assemble a device for use at home.
He was told they used off-
Shelf assembly and 9-volt batteries. The 40-
Hertz lights should be simple enough to be copied by people with electrical engineering skills;
Several accounts on YouTube have posted a schematic.
But in addition to the TheraNova engineer, Ed does not know anyone who has these skills.
To verify that the light is really flashing at 40Hz, an oscilloscope is needed, which costs thousands of pounds.
Still, he ordered a string of $40.
Hertz LED lights from a new online business, gammalighttherapy.
Com established in mid-August (
Its website refers to the research of MIT)
And another \"gamma bulb \".
He also searched 40-
Hertz sound posted on YouTube videos by New Age and brain hacker enthusiasts, who have been using this tone in meditation;
They pointed out that powerful gamma brains were found in research at the University of Wisconsin.
Waves of meditation by Tibetan Buddhist monks.
He and peeger began to listen for an hour on their headphones every day.
It seems to be helpful, but by the end of the night, peeger\'s confusion came back.
Ed continues to call and email Cognito and TheraNova\'s researchers for their help and gets angry when they don\'t respond.
On September 27, 12 days after Ed\'s last email, Zach Malchano, general manager and president of Cognito, wrote back.
He said he was very sad to hear about the decline in Peg, but there was no plan for further trials in San Francisco and the company was unable to provide unapproved medical equipment.
Malchano declined to be interviewed but emailed a statement stating that Cognito was not allowed to use research equipment even in the case of sympathy
Use the procedure because of the early stages of the \"scale and resources\" of research and cognition.
Malchano also wrote: \"Many of us have personal connections with the disease at Cognito, and is working as quickly and hard as possible to study the effectiveness of this technique in trials necessary to understand potential effectiveness and safety.
\"The Food and Drug Administration has approved almost all requests for compassionate use of seriously ill patients who lack a therapeutic alternative --
But only if medical developers agree.
Ed said it was unethical for researchers to abandon the link to her illness.
\"We are guinea pigs,
Ed said: \"We signed it on paper, but if you know that the plaque on the mouse will come back, then you can assume that the plaque on the people will come back and you have to solve the problem.
This is your moral responsibility.
\"It\'s like testing if a life raft works, and then throwing people back into the water,\" a friend said more clearly . \".
In gleason\'s experience, there are some reminiscent of \"The Flowers of Algernon\": the eager scientists, the improvement on the surface, and then the rapid, hopeless return.
Ed believes that MIT scientists, whose research is partly funded by the Federation, are also wrong in seeking ownership of technology and concepts.
\"They can\'t apply for 40Hz more than GM\'s 40 miles per hour patent,\" he said . \".
In fact, other researchers have studied the gamma brain. wave-
Induction device in human body.
A 2016 study by the University of Toronto reported that after six treatments with a built-in vibration acoustic treatment chair, the cognitive ability of Alzheimer\'s patients improved
The speaker is set to 40Hz.
The psychotherapist also used equipment to train brain waves through audio-visual stimulation and sold it to the public for 10 years.
Psychologist Ruth Omsted has written a 2005-issue Neurotherapy paper on audio-visual enfusions of learning disabilities, selling a \"synaptic stimulation trainer\" with headphones that looks like the device used in the San Francisco study.
Like other such devices that claim to increase creativity, treat depression and sleep disorders, or help children with learning disabilities, it is marketed with a disclaimer stating that it is only for \"entertainment\" purposes.
For her, Li
Cai Huiqing said that she was in contact with 40-
Hertz LED lights can cause damage, but DIY attempts in the brain
At some intensity, wave suction can be dangerous.
Result of \"extensive, strict, very good\"
Tsai said in a telephone interview that the necessary control and blind research may be completed in three to four years.
She declined to answer questions about the TheraNova study or 12-
A patient study is underway in Boston.
In her summer speech at Congress and on podcasts, TSAI ING-WEN was less cautious, saying she wanted 40-
Hertz\'s research will produce life-
For millions.
\"My dream is that maybe one day we can try to create a \'gamma society\',\" Tsai said \'. \".
\"We can try to change our lighting system (s)
At home or on the street, the refresh rate of a computer monitor or TV makes it easier for people to get access to gamma flashes, thus creating a healthy society.
\"Until then, Peg Gleason would have been of no help;
Probably long before the clinical trial. As of mid-
Her confusion and sunshine continued to deteriorate in November.
She was mistaken for her father again.
She did not want to listen to the sound, nor did she want to look at the lights, and he had given up looking for another device.
He hopes to continue to take care of her at home.
Experimental treatment of Alzheimer\'s disease was supported in last January.
The trial had a slightly odd environment in the warehouse office of TheraNova, San Francisco --based medical-
Equipment developers
Seven days a week, lasting seven months until the end of the study, 85-year-old Pegg and her husband Ed, Uber got off at the side door and was taken to a small room inside an old metal vault.
The experimenters are \"very good and smart people, they are all 32-and-a-half-
Ed, a retired product manager at & t, joked.
In a telephone interview, he said: \"They put very large sunglasses on the Peg and the lenses were blackened . \" Peg also took part in a telephone interview. “[They]
Attach very small LED lights to them so that when you turn them on, all you see is four small lights on each lens.
They will be calibrated to flash at 40Hz.
\"Along with the glasses, the Peg installed the headset, which played the tone at a frequency of 40Hz, and each hand had a cushion vibrating at that frequency.
The treatment lasted an hour a day and then another 15 minutes.
A cognitive test was conducted and the scavenger was driven home.
The San Francisco experiment began in last January. a month ago, the journal Nature published a research report from the Massachusetts Institute of Technology that was exposed to a flashing led light at 40Hz (
40 cycles per second)
Related to a significant reduction in betaStarch-like plaque
Abnormal protein mass-
In the visual cortex of mice developing Alzheimer\'s diseaselike disease.
Neurons in the brain sometimes move synchronously, producing brain waves.
Brain waves around 40Hz, in so-
Called gamma band.
Frequency associated with higher frequency
Sequential cognitive functions such as working memory and spatial navigation
It is well known that Alzheimer\'s disease and some other brain damageBased on disease.
Also destroyed the gamma properties ofmice improved varieties to develop Alzheimer\'s disease, Li, professor of neurology at the Massachusetts Institute of Technology
Cai Huixin, the lead author of Nature, explained this in a speech to the congressional panel on last July.
But she said that it took only one hour a day in the experimental mice in a box with LED lights, and after flashing at 40Hz, their gamma-ray brain waves bounced back and the starch-like plaques were reduced by half.
Mice can learn again.
\"They can remember an object in the environment, they can remember a place, they can navigate better,\" Tsai said . \".
TSAI ING-WEN said what happened
Hertz flashes the brain waves of the \"carrying\" mouse, synchronized at gamma frequency.
She said that the sync was initially shown on a cat in her 1990 s, pointing to a GIF where a cat stared at the flashing lights.
At present, it is not clear what is going on. TSAI ING-WEN continued, but the gamma-ray brain waves that restored mice also restored their small nerve cells, clear toxic substances such as starch-like protein and \"strike\" brain immune cells in Alzheimer\'s disease.
\"These gatekeeper cells, the small nerve cells, are active again,\" Cai said . \"
\"They are getting bigger and bigger, the branches are getting more complicated, and there are only more branches.
But more importantly, they are busy digesting the starch-like protein.
TSAI ING-WEN said another sign of Alzheimer\'s disease, nerve fiber winding, \"disappeared\" in experimental mice.
The blood vessels in their brains have also changed, lumens
Internal channel-
Double expansion.
\"But it didn\'t stop,\" she said . \"
\"In the brain of Alzheimer\'s, a large number of neurons die and the brain becomes smaller.
\"Contact 40-6 to 8 weeks a day
However, Hertz light \"protects brain cells from death and prevents brain atrophy.
Synaptic connections, density, are restored.
The most spectacular thing is that what makes Tsai English \"Speechless\" is that this effect spreads to other parts of the brain, \"including the hippocampus of the memory center, the prefrontal cortex is a part of the brain that is known to be important for decision-making and execution.
However, when the light stops, starch-like patches bounce back even if it is only 12 hours.
The frequency of flashing must reach 40Hz;
Other frequencies or random flashes have no effect.
TSAI ING-WEN and her colleagues checked and reviewed their findings.
\"We\'re excited, but we\'re anxious,\" she said . \"
\"This is an incredible and unexpected result.
We just have this anxiety, repeat as much as we can, and let as many different people repeat as possible.
\"In my wildest dreams, I never thought I \'d come across this kind of observation, this kind of deep, this kind of hard --to-
Tsai, head of the Institute for Learning and Memory at the Massachusetts Institute of Technology Picower, said on the podcast.
Last fall, shortly before the publication of the journal Nature, Tsai and her leading colleagues
The author is Edward, a professor at MIT.
Boyden founded a company called cognitive therapy.
With the support of MIT and the venture capital fund, the company aims to develop \"equipment-
Basic therapy for Alzheimer\'s and other neurological degeneration.
Cognito participated in the human feasibility study in San Francisco in last January.
Ed and Peg Gleason learned about this from a leaflet delivered by a friend at the University of California Medical Center.
They have nothing to lose;
Alzheimer\'s is the most common form of dementia and there is no cure yet.
It won\'t die soon, but as the brain gradually fails and the victim loses all the ability to communicate or take care of himself, it will last for months or years.
Alzheimer\'s disease is now the third leading cause of death in the United States.
In 2011, Peg was diagnosed when MRI at the time of routine physical examination found her frontal lobe atrophy.
\"When she explained that it was Alzheimer\'s, I looked at her and said, \'No, no, that\'s not me, I don\'t have any problems, \'she said. \'.
She ran out of the doctor\'s office crying.
Six years after that, she
The term memory has declined.
She rarely remembers what happened earlier in the day, or even something memorable, like a visit from one of their six children.
But within a few days after the start of the TheraNova trial, the memory of Peg was improved.
She began to remember what happened the day before, not always, but more often.
Their children commented on this.
After the meeting, peeger also seemed a bit pleased to tell ed that she felt good.
\"It will last two or three hours after each treatment,\" Ed said . \".
The researchers also seem optimistic about the results.
Two staff members told Ed that everyone in the pilot study
A total of 5 people signed up
There is progress.
However, about a month after the start of the trial, the experimenter announced the suspension of the trial.
\"They said, \'We are going to stop this study and make an assessment, \'said Ed. \'
\"I don\'t know what they\'re thinking.
I don\'t want to think we are guinea pigs and they want to see if there is a negative effect of a recession.
But within a few days, the DingTalk fell.
Ed said: \"I told them that the plaque is coming back;
Like fog from the ocean.
\"The researchers did not make it clear.
\"They will say, \'Time is up for the study and we will review where we are.
\"Eight days later, Ed got a call saying the trial was recovering and a car would pick them up again the next day.
After that, there was no rest at the daily meeting except for a few weekends until noonAugust.
Then, with a week and a half notice, the study was over.
The trials are being transferred to Boston, where Cognito headquarters is located, the researchers said.
Soon, Pegg fell again.
By the end of September, five weeks after the study ended, her short-term income dropped significantlyterm memory.
Ed said: \"her anxiety and sunset became more obvious and more chaotic.
She didn\'t recognize Ed for the first time.
Several times she thought Ed was her father.
She also walked twice, something that had not happened before.
Her grandmother and sister died of Alzheimer\'s disease two years ago.
\"One thing I want to know,\" said peeger, \"is how much I will expect.
I don\'t want to hurt him and the children.
As the trial drew to a close, Ed began to ask researchers to allow Peg to continue her daily treatment or to help assemble a device for use at home.
He was told they used off-
Shelf assembly and 9-volt batteries. The 40-
Hertz lights should be simple enough to be copied by people with electrical engineering skills;
Several accounts on YouTube have posted a schematic.
But in addition to the TheraNova engineer, Ed does not know anyone who has these skills.
To verify that the light is really flashing at 40Hz, an oscilloscope is needed, which costs thousands of pounds.
Still, he ordered a string of $40.
Hertz LED lights from a new online business, gammalighttherapy.
Com established in mid-August (
Its website refers to the research of MIT)
And another \"gamma bulb \".
He also searched 40-
Hertz sound posted on YouTube videos by New Age and brain hacker enthusiasts, who have been using this tone in meditation;
They pointed out that powerful gamma brains were found in research at the University of Wisconsin.
Waves of meditation by Tibetan Buddhist monks.
He and peeger began to listen for an hour on their headphones every day.
It seems to be helpful, but by the end of the night, peeger\'s confusion came back.
Ed continues to call and email Cognito and TheraNova\'s researchers for their help and gets angry when they don\'t respond.
On September 27, 12 days after Ed\'s last email, Zach Malchano, general manager and president of Cognito, wrote back.
He said he was very sad to hear about the decline in Peg, but there was no plan for further trials in San Francisco and the company was unable to provide unapproved medical equipment.
Malchano declined to be interviewed but emailed a statement stating that Cognito was not allowed to use research equipment even in the case of sympathy
Use the procedure because of the early stages of the \"scale and resources\" of research and cognition.
Malchano also wrote: \"Many of us have personal connections with the disease at Cognito, and is working as quickly and hard as possible to study the effectiveness of this technique in trials necessary to understand potential effectiveness and safety.
\"The Food and Drug Administration has approved almost all requests for compassionate use of seriously ill patients who lack a therapeutic alternative --
But only if medical developers agree.
Ed said it was unethical for researchers to abandon the link to her illness.
\"We are guinea pigs,
Ed said: \"We signed it on paper, but if you know that the plaque on the mouse will come back, then you can assume that the plaque on the people will come back and you have to solve the problem.
This is your moral responsibility.
\"It\'s like testing if a life raft works, and then throwing people back into the water,\" a friend said more clearly . \".
In gleason\'s experience, there are some reminiscent of \"The Flowers of Algernon\": the eager scientists, the improvement on the surface, and then the rapid, hopeless return.
Ed believes that MIT scientists, whose research is partly funded by the Federation, are also wrong in seeking ownership of technology and concepts.
\"They can\'t apply for 40Hz more than GM\'s 40 miles per hour patent,\" he said . \".
In fact, other researchers have studied the gamma brain. wave-
Induction device in human body.
A 2016 study by the University of Toronto reported that after six treatments with a built-in vibration acoustic treatment chair, the cognitive ability of Alzheimer\'s patients improved
The speaker is set to 40Hz.
The psychotherapist also used equipment to train brain waves through audio-visual stimulation and sold it to the public for 10 years.
Psychologist Ruth Omsted has written a 2005-issue Neurotherapy paper on audio-visual enfusions of learning disabilities, selling a \"synaptic stimulation trainer\" with headphones that looks like the device used in the San Francisco study.
Like other such devices that claim to increase creativity, treat depression and sleep disorders, or help children with learning disabilities, it is marketed with a disclaimer stating that it is only for \"entertainment\" purposes.
For her, Li
Cai Huiqing said that she was in contact with 40-
Hertz LED lights can cause damage, but DIY attempts in the brain
At some intensity, wave suction can be dangerous.
Result of \"extensive, strict, very good\"
Tsai said in a telephone interview that the necessary control and blind research may be completed in three to four years.
She declined to answer questions about the TheraNova study or 12-
A patient study is underway in Boston.
In her summer speech at Congress and on podcasts, TSAI ING-WEN was less cautious, saying she wanted 40-
Hertz\'s research will produce life-
For millions.
\"My dream is that maybe one day we can try to create a \'gamma society\',\" Tsai said \'. \".
\"We can try to change our lighting system (s)
At home or on the street, the refresh rate of a computer monitor or TV makes it easier for people to get access to gamma flashes, thus creating a healthy society.
\"Until then, Peg Gleason would have been of no help;
Probably long before the clinical trial. As of mid-
Her confusion and sunshine continued to deteriorate in November.
She was mistaken for her father again.
She did not want to listen to the sound, nor did she want to look at the lights, and he had given up looking for another device.
He hopes to continue to take care of her at home.
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