it is time to test low level laser therapy in great britain
Over the years, it has been used in Eastern Europe and Asia to treat various diseases.
Its continued acceptance in these populations reflects the efficacy of clinicians and their patients on it.
Although there have been a large number of reports on its clinical benefits and some practitioners have used the technology in North America and Australia, detailed assessments have not yet been conducted through randomized clinical trials.
The purpose of this review is to stimulate interest in the technology and encourage rigorous research into its potential value.
Low intensity laser therapy (LLLT)
For more than 30 years, clinical investigations and use have been conducted mainly in Eastern Europe and Asia.
The ability of laser cutting, burning, and destroying tissues is well known throughout the medical community.
However, its role in lower power is less popular.
Hot and non
Destructive changes in cell function, known as laser biological stimulation, are the basis for the use of lasers in many medical fields at present.
Global interest in LLLT is reflected in its use in more than 85 institutions in 37 countries.
Since reporting the first study in 1967, about 2500 papers have been published in various journals around the world, and LLLT\'s value is much better than many think.
Its scientific background is sufficient to show that it is safe and effective.
Unfortunately, however, a positive double-blind study is not easy to find.
Of the 100 people selected for evaluation in this review, only 28 were found on Medline.
Many studies are published in regional or national publications that are not indexed on Medline or similar databases.
The main reasons for this restriction on publication include language barriers and the lack of professional journals due to funding constraints.
Table 1 summarizes published studies on the treatment of cardiovascular diseases with low-intensity laser.
View this table: View inline View pop-up table 1. Published summary of low-intensity laser treatment of cardiovascular diseases most reports are in Russian, the basis of clinical research and practice was first established in Moscow in 1986
The Institute of Laser Medicine consists of 14 Laser Centers from different regions of Russia.
Because of the transformation of military production into the field of commercial practice, including medicine, LLLT has become a potential treatment.
The largest laser research center was built in the closed city of Kaluga, which was opened on 1995 by the Russian government.
As a result, clinicians in Russia and Ukraine now have access to a wide range of invasive and non-invasive
There are many specialized laser centers in these countries.
A wide range of laser applications have been used to treat a large number of patients, up to 1 in the last time.
5 million patients are treated each year.
The reason why LLLT is widely used in Russia and Ukraine is obvious.
Today, expensive medicines and advanced technologies dominate medicine. The ever-
The emergence of drug-resistant bacteria and the increased sensitivity of patients to drugs should encourage the search for new treatments.
Laser irradiation has shown special hope in this area, with few taboos and limited side effects.
However, there are some taboos using LLLT that include: malignant tumors located in the post-irradiation epilepsy area, during pregnancy, thyroid glandire radiation in the abdomen has a slight high-sensitivity thrombosis in the pelvic vein or deep veins of the legs.
Today, people understand more about the effect of laser on biochemistry and cell function than they did 20 years ago, and propose the following benefits: increased metabolic activation and functional activity of cells (
ATP synthesis increased by up to 150%)
1 The repair process is stimulated due to the increase in cell proliferation2-4anti
Inflammatory effects 1, 2 microcirculation activation and more effective tissue metabolism 1, 5-7 analgesic effect due to increased immune stimulation of endorphin release 8, 9, 10, 11, corrected the normalization of acid-base balance in 12, 13 stable cell membranes of lipid peroxide 5, 6, 14 stimulating red blood cells 1, 13, 15 vascular expansion 3, 6, 12 blood 18 (fig 1)
Download the mechanism of action of figureOpen low-intensity laser therapy in the new tabDownload powerpoint figure 1.
There are indications that LLLT also works: During post-traumatic recovery, or in the event that diet and drug intervention is ineffective in enhancing immune response, treatment for high blood fat.
In addition, Ohshiro and calderhead 19 believe that low-intensity laser irradiation may play a role through the effects on the central nervous system.
They believe this is achieved through tissue light activation, in which the energy level of the biological structure changes through quantum absorption of light.
The body absorbs light energy, stimulates and changes the metabolic process.
It causes the reorganization of protein polymers.
In particular, it changes the structure and functional properties of the membrane and fermentation process.
In this way, it has some similarities with the role of sunlight in plant photosynthesis.
Judging from more than 10 years of practical experience with low-intensity laser irradiation in Ukrainian cardiology, it is clear that it offers new therapeutic possibilities.
These include the improvement of the flow properties of blood and blood circulation, as well as the normalization of hormone and immune parameters.
4, 13, 16, 17, especially LLLT, can be part of a range of treatment modalities in patients with ischemic heart disease in which it can reduce the risk of acute myocardial infarction.
In 10 years, one of the authors (TM)
About 500 out-patient patients with the disease were studied, and 60% patients received laser treatment twice or more.
About 70% of patients received positive clinical benefits.
There are two basic techniques in methodology.
Laser blood irradiation of vein (ILBI)
By the HeNe laser in the red spectrum and the laser in the infrared spectrum at the same time, the projection of the reflection and acupuncture area is irradiated.
From practical experience, TM considers this to be the best combination of treatment, but remains to be confirmed in a double-blind trial.
Twenty-year-old Russian researcher Meshalkin and Sergievskiy developed intravenous laser blood irradiation in experiments and introduced clinical practice in 1981.
Initially, this method was applied to the treatment of cardiovascular abnormalities.
Now, the first method commonly used in this case is HeNe laser (632. 8 nm)
Irradiation of blood through a venous catheter.
The usual parameters are: In the case of exposure for 10-60 minutes, output at the end of the light guide inserted into the 1 mW to 4 mW vein.
The program has 3 to 10 meetings per day or every other day.
The second treatment is to use the wavelength to reach through the skin (830 nm)
Output 40 mw, frequency 5Hz.
The infrared laser irradiation of the skin is for the heart projection and Zakaryan-Head’s zones (fig 2).
The program has 6 to 10 meetings per day or every few days.
Light activation in the infrared spectrum laser reflection area stimulates the regulation mechanism of nerves and body fluids.
This method is used for the treatment and prevention of coronary heart disease, arrhythmia, 17,18, 21 diabetes, 5 hypertension and occlusion vascular disease.
Download figureOpen new tabDownload powerpointFigure 2 release Reflexogenic areaZaharyan’s-Head’s areas)
In terms of coronary heart disease
The area of the body or head.
Related personnel: G Zaharyan (1827–1897)
Sir Henry Hyde1861–1940).
Reference: head H
With regard to sensory disorders, particular reference is made to the pain of visceral diseases.
Brain 1893: 16:1-133; Brain 1894; 17:339–480; Brain 1896; 19:153–276.
Description: skin pain sensitive areas associated with visceral diseases.
On 1883, Russian doctor G Zaharyan discovered the field of \"joint organ representation.
Ten years later, Sir Henry Hyde was the first to describe signs of disease reflex, and he showed how obstacles to any internal function were quickly reflected on the surface of the external body, so, notice of disorder, for example, attributed to the feeling of internal organs, neck, and chin pain can be seen in coronary heart disease.
In lateral branch stimulation, organ disease can cause hypersensory or pain in the nerve from the skin area in the same part of the spine.
Laser irradiation stimulation of these \"organ representation\" regions may affect the physiological functions of these organs by stimulating the nerve ends. (
Meditsina Reprinted with permission, Moscow).
Laser blood irradiation by intravenous injection of HeNe (IV HeNe LBI)
It has a wide range of effects, including biological stimulation, pain relief, anti-allergic effects, immune regulation, vascular expansion, anti-arrhythmia, 4,18, 22 anti-hypoxia, anti-spas and-
In addition, when resistant to nitrate, 2,16, 17β blocking drugs and calcium channel blocking drugs, iv lbi procedures for patients with ischemic heart disease may be helpful.
The effects reported in 18 and 22 include reducing the demand for sodium nitrate tablets, reducing the number of attacks of coronary heart disease, reducing pain, inhibiting lipid peroxide, and increasing the antioxidant protection of red blood cell membranes, reduce the normalization of fibrogenic anti-thrombosis
III. Decreased brain wave activity-
Axis of the gland, andrenin-
23, 24IV LBI improves the flow properties of the blood, increases the fluidity of the blood, and activates the transportation function.
This is accompanied by an increase in oxygen levels and a decrease in CO 2 pressure.
The increase in the difference in oxygen between arteries and veins confirms the decrease in tissue hypoxia and returns to normal metabolism.
It is possible that the basis for activation of oxygen transport by iv lbl is through the effect on hemoglobin.
The increase in oxygen levels improves the metabolism of the tissue.
In addition, laser irradiation activates ATP synthesis and energy formation in cells.
24 the application of iv lbi in cardiology indicates that the operation has an analgesic effect, increasing the patient\'s motor tolerance and prolonging the remission period.
The mechanism may be to increase the flow of peripheral blood and tissue oxygenation by reducing platelet aggregation and fiber-soluble activation.
The improvement of blood circulation can also be attributed to changes in vascular expansion and the physical and chemical properties of red blood cells.
In particular, their negative charges have increased.
In addition, the smooth flow of blood vessels and collateral and the normalization of smooth muscle nerve excitement in the blood vessel wall.
The individualized dose of intravenous LBI is an important factor in ensuring successful treatment.
This technology solves the problem of \"secondary aggravation\" of the disease during laser treatment.
This phenomenon depends on the initial exposure and output power of the irradiation.
In the first process, the initial dose should be minimal and then gradually increase to the fifth process.
For patients with coronary heart disease under 60 years of age, the output power at the end of the venous light guide should range from 2 mW to 4 mW, initially exposed to blood for 7 to 8 minutes as a standard method.
During the fifth operation, the exposure time was subsequently increased by 15 minutes.
For patients over 60 years of age, exposure is reduced.
The usual parameters for blood irradiation in this group of patients are the output power of 1 mW to 3 mW venous light guide ends, five minutes of exposure during the first operation and 10 minutes during the fifth operation.
The simple method of personalizing this laser treatment process is based on observing the phenomenon of \"scarlet red blood.
This can be seen when putting the venous catheter with the light guide into the vein.
During the third to fifth procedure of intravenous injection of LBL, the occurrence of this phenomenon coincides with the production of no.
No is an endothelial relaxation factor involved in blood circulation, immune function, communication between nerve cells, and the flow properties of blood and coronary artery microcirculation.
No plays a key role in maintaining vascular expansion and reducing hypertension.
However, excessive nitrogen oxides are harmful and cause oxidation damage.
These harmful effects can be limited by the use of antioxidants, such as complexes of two vitamins A and E ,(AEVIT).
This \"arterial\" of the patient\'s blood means that the operation should be suspended or not performed frequently (
Every two to three days instead of every day).
Sometimes the symptoms of hypercoagulation are consistent with the appearance of \"scarlet red blood\", which may limit the clinical efficacy.
The biological effects of laser under various conditions are complex and more research is needed to find the best treatment parameters.
Scientific research and clinical experiments on LLLT will help to confirm whether it has a clear role in the treatment and prevention of ischemic heart disease.
While some may think LLLT is a magical electrotherapy panacea, others think it\'s useless, clinical researchers need to look at these new laser medical devices at the moment.
More research is needed to obtain data on the success rate of treating a specific disease.
This should include exposure time, frequency of treatment, and related treatment options.
These studies must meet strict criteria and clearly have a place in a double-blind, randomized controlled trial.
Only when reliable data are obtained from such a rigorous study will LLLT be accepted as an effective treatment.
However, the clinical experience described in this article should be a tip for LLLT equipment manufacturers to fund this work.
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Conflict of interest: no announcement.